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While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk
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However, three distinct lines of male mice deficient in leptin or leptin signaling, i.e., ob/ob , db/db and Lepr flox/flox;Emx1-Cre mice, exhibited different patterns of downregulation of exon-specific Bdnf gene expression, with ob/ob associated with decreased expression of exons II, III, IV, and VI, db/db associated with decreased expression of exons I, III, and IV and Lepr flox/flox;Emx1-Cre associated with decreased expression of exons I, II, IV, and VI
Bull Exp Biol Med
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